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POCT Brings Benefits to Maternal and Infant Safety

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POCT Brings Benefits to Maternal and Infant Safety
POCT Brings Benefits to Maternal and Infant Safety

POCT Brings Benefits to Maternal and Infant Safety

Compared with the laboratory equipment, the POCT device is small, convenient and instant, now it is widely used in clinical practice.

Fast, accurate and convenient detection methods are of great significance for the diagnosis and treatment of the diseases of pregnant women and newborns. And it has great meaning in reducing the mortality rate of pregnant women and newborns.

Therefore, immediate and rapid POCT has an unparalleled advantage in obstetrics.


Testing of NT-proBNP


Pregnancy with heart disease is a serious complication of obstetrics, with an incidence of 0.5%-3.0%, which is one of the top three causes of maternal death.
Pregnancy with heart disease is mainly divided into structural abnormal heart disease, dysfunctional heart disease and heart disease specific to pregnancy, such as hypertensive acute heart disease and peripartum cardiomyopathy.
Heart failure, pulmonary hypertension, and pulmonary hypertension, malignant arrhythmia, and infective endocarditis are major complications of pregnancy with heart disease.


The diagnosis of pregnancy with heart disease should be combined with medical history, symptoms, signs and auxiliary examinations.

As an important part of the auxiliary examination, the levels and heart of heart failure biomarker brain natriuretic peptide (BNP), B-type natriuretic peptide precursor (proBNP) and N-terminal B-type natriuretic peptide precursor (NT-proBNP) The severity of aging is positively correlated, and its level can reflect the degree of myocardial function and damage in pregnant women, helping obstetricians to detect pregnancy and heart disease in time.


NT-proBNP is a well-recognized indicator for the diagnosis of acute heart failure. However, the diagnostic criteria for maternal maternal disease have not been thoroughly studied. Therefore, the maternal heart failure can be evaluated clinically with reference to the criteria of the normal population.


When the level of NT-proBNP is <400pg/mL, the risk of heart failure is small; when the level is between 400-1500pg/mL, it needs to be properly diagnosed and treated with clinical symptoms; when the level is >1500pg/mL, heart failure It is more likely to be treated according to clinical manifestations; when the level is >10000pg/mL, it is likely that the heart failure is serious and needs to be closely monitored.


In addition, BNP, proBNP and NT-proBNP are also of great value in the prognosis assessment and efficacy monitoring of patients with heart failure.

Compared with BNP, NT-proBNP is more stable and has fewer interference factors. It has a strong correlation with cardiac function compensation (NYHA classification), which can help obstetricians to more objectively and quantitatively judge heart function status and women with heart disease. The risk of pregnancy is assessed.

The two criteria for risk assessment and cardiac function grading in pregnancy are guidelines and benchmarks for the management of pregnant women with heart disease. Pre-pregnancy, early pregnancy, and mid-pregnancy should be assessed for cardiac function to determine whether it is inappropriate for pregnancy. Or if you need to terminate your pregnancy.


Testing of PH value


In addition to the use in diagnosis of heart disease of the pregnant, it is also applicable to the diagnosis of neonatal asphyxia in obstetrics.

According to data released by the World Health Organization (WHO) in 2011, neonatal asphyxia accounted for 23% of neonatal deaths. In addition, neonatal asphyxia is also an important cause of neonatal disability, hypoxic ischemic encephalopathy, and brain damage.


In the diagnosis of neonatal asphyxia and cerebral palsy, the Apgar score for rapid assessment of neonatal health is widely used clinically, but it still has its limitations.

Because the Apgar score is susceptible to neonatal conditions, physiological maturity and various medications during pregnancy, it leads to many false apnea diagnose, the cord blood test is an effective supplement to the Apgar score. Diagnosing neonatal asphyxia is of great value.


The most important parameter among the parameters of cord blood and blood gas is the pH value.

After the influence of maternal acidosis is excluded, the pH value can reflect the hypoxia and hypercapnia of the child, and the result is relatively stable and cannot change in a short time

The pH value is used as an indicator for judging blood gas abnormality.

It is suggested that in addition to the high-risk factors leading to neonatal asphyxia, the necessary diagnostic indicators include: 1 or 5 min Apgar score ≤ 7 points, effective spontaneous breathing has not been established; umbilical arterial blood gas analysis pH < 7.15; other causes low Apgar The cause of the score.


POCT has the advantages of accuracy, portability, rapidity, networking and quality control management, which can speed up the differential diagnosis of obstetric emergency and critical illness, and provide important clinical value for obstetricians in the diagnosis and treatment of pregnancy combined with heart disease and neonatal comprehensive management.

Pub Time : 2019-08-22 14:05:58 >> News list
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